Van de Ven Double Halts The Toffees' Unbeaten Streak at Brand New Stadium
The Dutch defender emerged as the initial defender to net twice in a English top-flight match for Tottenham since Jan Vertonghen in March 2013.
At a glance
The Spurs defender heads home two times in first half
Everton's Jake O'Brien has equalizer ruled after VAR review
Senegalese midfielder nets final goal in dying moments
The defeat is Everton's initial at Hill Dickinson Stadium
The Tottenham defender scored on two occasions as Spurs extended their unbeaten run on the road in the top division and delivered the Toffees their first defeat at their new home.
The Toffees were unbeaten in their last five matches at their new ground at Bramley-Moore Dock, having left Goodison Park behind after more than a century at the conclusion of the previous campaign.
But Tottenham's leader Van de Ven struck on two occasions from set-pieces in the opening 45 minutes to put their strong form at jeopardy, and they were failed to turn it around before the midfielder - assisted by ex-Everton forward Richarlison - nodded in a third to seal the victory.
The Everton defender believed he had equalized the tally five minutes after Van de Ven's opener, directing a bullet header past the Spurs keeper from an set-piece.
The Portuguese striker, meanwhile, missed a number of chances, while Vicario made a succession of excellent saves to ensure the London club went five matches on the road without defeat in the Premier League.
But the video assistant referee stepped in, instructing the match official to review the goal on the pitchside monitor and the referee ruled that the winger and Iliman Ndiaye were in offside positions and had impeded with the Tottenham goalkeeper.
This victory elevates Thomas Frank's side up to third in the Premier League, a handful of points off local foes and table-toppers the Gunners.
Everton stay 14th and sit six points ahead of the drop zone.
Tottenham analysis: The defender fulfils duties at both ends of pitch
After a uninspiring midweek performance in the Champions League against Monaco, where they mustered a mere two shots on goal, the manager chose Randal Kolo Muani up front instead of former Toffees player Richarlison.
The summer signing was failed to make much of an impact before being substituted for the substitute after an hour on the field, but it emerged he proved unnecessary in the end.
Defender the Dutchman transformed into an attacking force to be reckoned with.
Tottenham's first goal came from a cleverly executed set-piece play, with the midfielder directing the ball back across the six-yard box for an free Van de Ven to score.
And the captain - stepping up as skipper in the Argentine's absence - added his next goal in added time as he rose above Jordan Pickford to nod in.
Van de Ven was just as impressive in defence, partnering effectively with his defensive colleague as the pair handled excellently with the numerous deliveries sent their way by the opposition.
Toffees breakdown: Toffees lacking finishing touch
Everton's recent stadium had been a happy hunting ground, but it appears the freshness may have worn off somewhat and supporters flocked to the gates after Sarr's final goal for Spurs.
The end in Everton's unbeaten home run will not be a massive concern for the manager, but their attacking woes are.
The forward and Thierno Barry - the Everton's pair of recognised centre-forwards - had scored only one league goal between them before Sunday's match.
And they were failed to add to that miserable tally on a damp and dreary night on Merseyside.
Beto's performance was epitomized when he opted to overhead kick a golden opportunity from close range, despite having room and opportunity to reposition for a more conventional shot that would have tested the keeper.
Barry, as well, was unable to influence the game after coming on for Beto in the 65th minute.
It wasn't for a shortage of chance. Most of Everton's attacks came through Grealish and the forward, who tirelessly whipped threatening balls into the Tottenham box.
What next for both teams?
Everton: Moyes' men head to the Stadium of Light in the Premier League on Monday, 3 November at 8 PM.
Tottenham: Spurs go to St James' Park on late October for their next round League Cup match against the Magpies.